Health Guide

Thrombopoietin of the liver is like Erythropoietin of the kidney. ✅ Failure of kidney ➡️ Anemia. ✅ Failure of liver ➡️ Thrombocytopenia. However,  "Despite thrombocytopenia in liver disease, there is an increased risk of thrombosis". Why there is increased risk of THROMBOSIS in liver disease despite having thrombocytopenia? ⬇️ 1. Reduced synthesis of anticoagulant proteins, such as protein C, protein S, and antithrombin, by the damaged liver cells. 2. Increased levels of factor VIII, a procoagulant protein, due to reduced clearance by the dysfunctional liver and increased production by the inflamed endothelium. 3. Activation of the coagulation cascade by endotoxins, cytokines, and tissue factor released from the injured liver or bacterial translocation. 4. Impaired fibrinolysis due to increased levels of plasminogen activator inhibitor-1 (PAI-1) and decreased levels of tissue plasminogen activator (tPA). 5. Reduced blood flow and increased viscosity in the portal...